Restoration of Germinal Epithelium with Usage of Antioxidant Oils in Phenytoin Induced Testicular Toxicity: A Comparative Study in Rats

Objective: To evaluate antioxidant effect of Virgin Coconut Oil (VCO) and Corn (CO) on germinal thickness (GT) in rats induced with phenytoin toxicity. Study design setting: An Experimental Longitudinal study was done at AL-Tibri Medical College Hospital Isra University Karachi Campus. Methodology: 28 male albino were selected divided into 4 groups each consisting 7 rats. Group A received normal saline solution only, B 10mg/kg/body weight Phenytoin, C VCO+ D CO+ Phenytoin. Animals euthanized the 4th, 5th, & 6th week tissue sample acollected for measuring GT using stage micrometer. Data analyzed SPSS 20.0. All values expressed as mean ± S.D., compared One way ANOVA followed by Post hoc Tukey’s test p- value <0.05. Results: significant difference seen comparing it against group (P-value: <0.001, 0.001). On (VCO + Phenytoin) &< No when (CO to (p-value: 0.551, 0.954, 0.931). Conclusion: can reduce negative caused toxicity preventing thinning layer.